Symbol
Name
ID

Sos1
SOS Ras/Rac guanine nucleotide exchange factor 1
MGI:98354

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes	Abnormal bleeding	Bruising susceptibility	Juvenile myelomonocytic leukemia	Abnormality of coagulation	Reduced factor VIII activity	Reduced factor XI activity	Prolonged partial thromboplastin time	Abnormal platelet function	Thrombocytopenia	Abnormality of the spleen
Disease(s) Associated with SOS1	Abnormal bleeding	Bruising susceptibility	Juvenile myelomonocytic leukemia	Abnormality of coagulation	Reduced factor VIII activity	Reduced factor XI activity	Prolonged partial thromboplastin time	Abnormal platelet function	Thrombocytopenia	Abnormality of the spleen
Noonan syndrome
Noonan syndrome 4

Mouse Phenotypes

decreased T cell proliferation

decreased thymocyte number

decreased DN4 thymocyte number

enlarged spleen

abnormal common myeloid progenitor cell morphology

abnormal erythropoiesis

decreased double-negative T cell number

decreased double-positive T cell number

extramedullary hematopoiesis

increased megakaryocyte cell number

increased neutrophil cell number

decreased CD4-positive, alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

decreased gamma-delta T cell number

increased leukocyte cell number

increased spleen red pulp amount

Availability

Mouse Genotype

Sos1^tm1.2Rak/Sos1⁺

Sos1^tm1.1Les/Sos1^tm1.1Les
Tg(Lck-cre)1Cwi/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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